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Physical Pharmaceutics-I Book B.Pharm 3rd Sem

Physical Pharmaceutics-I Book B.Pharm 3rd Sem

Rs. 235.00
Rs. 235.00
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B.Pharm.,Third Semester
According to the syllabus based on ‘Pharmacy Council of India’
Syllabus
 
Module 01                                                                                                                           10 Hours
 
Solubility of Drugs
Solubility expressions, mechanisms of solute solvent interactions, ideal solubility parameters, solvation and association, quantitative approach to the factors influencing solubility of drugs, diffusion principles in biological systems. Solubility of gas in liquids, solubility of liquids in liquids, (Binary solutions, ideal solutions) Raoult’s law, real solutions. Partially miscible liquids, Critical solution temperature and applications.
Distribution law, its limitations and applications.
 
Module 02                                                                                                                            10Hours
 
States of Matter and Properties of Matter
State of matter, changes in the state of matter, latent heats, vapour pressure, sublimation
critical point, eutectic mixtures, gases, aerosols – inhalers, relative humidity, liquid complexes, liquid crystals, glassy states, solid- crystalline, amorphous and polymorphism. Physicochemical Properties of Drug Molecules Refractive index, optical rotation, dielectric constant, dipole moment, dissociation constant, determinations and applications.
 
Module 03                                                                                                                           08 Hours
 
Surface and Interfacial Phenomenon
Liquid interface, surface and interfacial tensions, surface free energy, measurement of surface and interfacial tensions, spreading coefficient, adsorption at liquid interfaces, surface active agents, HLB Scale, solubilisation, detergency, adsorption at solid interface.
 
Module 04                                                                                                                           08 Hours
 
Complexation and Protein Binding
Introduction, Classification of Complexation, Applications, methods of analysis, protein
binding, Complexation and drug action, crystalline structures of complexes and thermodynamic treatment of stability constants.
 
Module 05                                                                                                                           07 Hours
 
pH, Buffers and Isotonic Solutions
Sorensen’s pH scale, pH determination (electrometric and calorimetric), applications of buffers, buffer equation, buffer capacity, buffers in pharmaceutical and biological systems, buffered isotonic solutions.
 
Practical
 
                                                                                                                                4Hrs/week
1)       Determination the solubility of drug at room temperature
2)       Determination of pKa value by Half Neutralization/ Henderson Hasselbalch equation.
3)       Determination of Partition co- efficient of benzoic acid in benzene and water.
4)       Determination of Partition co- efficient of Iodine in CCl4 and water.
5)       Determination of % composition of NaCl in a solution using phenol-water system by CST method.
6)       Determination of surface tension of given liquids by drop count and drop weight method.
7)       Determination of HLB number of a surfactant by saponification method.
8)       Determination of Freundlich and Langmuir constants using activated char coal.
9)       Determination of critical micellar concentration of surfactants.
10)   Determination of stability constant and donor acceptor ratio of PABA-Caffeine complex by solubility method.
11)   Determination of stability constant and donor acceptor ratio of Cupric-Glycine complex by pH titration method.


 

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