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Pharmaceutical Organic Chemistry-II Book B.Pharm 3rd Sem
Pharmaceutical Organic Chemistry-II Book B.Pharm 3rd Sem
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B.Pharm.,Third SemesterAccording to the syllabus based on ‘Pharmacy Council of India’
SyllabusModule 01 10 HoursBenzene and Its DerivativesAnalytical, synthetic and other evidences in the derivation of structure of benzene, Orbital picture, resonance in benzene, aromatic characters, Huckel’s rule.Reactions of benzene - nitration, sulphonation, halogenation- reactivity, Friedelcrafts alkylation- reactivity, limitations, Friedelcrafts acylation.Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic substitution reaction.Structure and uses of DDT, Saccharin, BHC and Chloramine. Module 02 10 HoursPhenols*Acidity of phenols, effect of substituents on acidity, qualitative tests, Structure and usesof phenol, cresols, resorcinol, naphthols.Aromatic Amines*Basicity of amines, effect of substituents on basicity, and synthetic uses of aryldiazonium saltsAromatic Acids*Acidity, effect of substituents on acidity and important reactions of benzoic acid. Module 03 10 HoursFats and OilsFatty acids – reactions.Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils.Analytical constants – Acid value, Saponification value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value – significance and principle involved in their determination. Module 04 08 HoursPolynuclear HydrocarbonsSynthesis, reactions.Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their derivatives. Module 05 07 HoursCycloalkanes*Stabilities – Baeyer’s strain theory, limitation of Baeyer’s strain theory, Coulson andMoffitt’s modification, Sachse Mohr’s theory (Theory of strainless rings), reactions ofcyclopropane and cyclobutane only.
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